Regulatory perspective on clinical trials and end points for female sexual dysfunction, in particular, hypoactive sexual desire disorder: formulating recommendations in an environment of evolving clinical science
نویسندگان
چکیده
منابع مشابه
Circuits of sexual desire in hypoactive sexual desire disorder.
What Is HSDD? For both patients and health care providers, HSDD probably should mean “Having the Sexual Dysfunction Discussion” to diagnose and treat distressful conditions,1 but it really stands for Hypoactive Sexual Desire Disorder. The DSM-IV defines it as the persistent or recurring deficiency (or absence) of sexual fantasies or thoughts or desire for sexual activity associated with persona...
متن کاملSexual desire and the female sexual function index (FSFI): a sexual desire cutpoint for clinical interpretation of the FSFI in women with and without hypoactive sexual desire disorder.
INTRODUCTION A validated cutpoint for the total Female Sexual Function Index scale score exists to classify women with and without sexual dysfunction. However, there is no sexual desire (SD) domain-specific cutpoint for assessing the presence of diminished desire in women with or without a sexual desire problem. AIMS This article defines and validates a specific cutpoint on the SD domain for ...
متن کاملWhat Sexual Behaviors Relate to Decreased Sexual Desire in Women? A Review and Proposal for End Points in Treatment Trials for Hypoactive Sexual Desire Disorder
INTRODUCTION Counts of satisfying sexual events (SSEs) per month have been criticized as an end point in treatment trials of women with hypoactive sexual desire disorder (HSDD) but grounding improvement in sexual desire by assessing changes in sexual behavior remains of some importance. METHODS We conducted a literature review to find validated measurements that are specific sexual behavioral...
متن کاملFemale hypoactive sexual desire disorder: History and current status.
INTRODUCTION Hypoactive sexual desire disorder (HSDD) is a common problem that is often treatment refractory. This refractoriness to treatment is reflective of our lack of knowledge concerning the determinants of sexual libido in women. AIM To review the development and current status of information concerning the diagnosis and treatment of HSDD. METHODOLOGY Literature on HSDD published bet...
متن کاملFlibanserin for Treating Hypoactive Sexual Desire Disorder
There have been several products developed for male sexual dysfunction. However, developing agents for female sexual dysfunction is lagging behind for various reasons. Sildenafil citrate (Viagra) and Tadalafil (Cialis), which have been prescribed for male sexual function disorders, are known to act on vessels.[1] On the other hand, flibanserin is thought to act on brain. Flibanserin has been ap...
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ژورنال
عنوان ژورنال: International Journal of Impotence Research
سال: 2006
ISSN: 0955-9930,1476-5489
DOI: 10.1038/sj.ijir.3901481